Paediatric brain cancer is a rare but often deadly disease, so biobanking forms an important part of research. Dr Endersby will discuss the structure of the Telethon Kids Cancer Centre biobank, which includes not only frozen and FFPE samples, but viable cells in culture, and a “clinic” of mouse avatars bearing implanted cancer cells. These samples are being actively used in clinical and preclinical research for the development of new therapies. Dr Endersby will also discuss how we engage our child donors, and their families, in our long-term research projects with particular focus on the importance of quality stakeholder engagement. Our community engagement is vital to the success of our biobank and the effective use of these precious resources. Dr Buck, a Kamilaroi researcher, will expand on this from an Indigenous perspective, and discuss the community engagement and challenges involved in undertaking biological research in the Aboriginal Health space, including cultural considerations and the importance of an Aboriginal research team.